Read the latest news from the Division of Hematology/Oncology including awards, publications and announcements.
- Alicia Morgans, MD, MPH receives 2017 PCF Challenge Award for her project SEARCH: Survivorship Enhancement in Men with Prostate Cancer At Risk for Poor Cognitive Health During Treatment with ADT.
An international team of scientists has pinpointed the genetic drivers of diffuse large B-cell lymphoma — the most common type of blood cancer — and determined the genes’ clinical significance. The study, published in the journal Cell, provides important insights for the development of future therapies.
Leo I. Gordon, MD, the Abby and John Friend Professor of Cancer Research, was a co-author of the study.
Suicide molecules kill any cancer cell
Small RNA molecules originally developed as a tool to study gene function trigger a mechanism hidden in every cell that forces the cell to commit suicide, reports a new Northwestern Medicine study, the first to identify molecules to trigger a fail-safe mechanism that may protect us from cancer.
The mechanism -- RNA suicide molecules -- can potentially be developed into a novel form of cancer therapy, the study authors said.
Cancer cells treated with the RNA molecules never become resistant to them because they simultaneously eliminate multiple genes that cancer cells need for survival.
“It’s like committing suicide by stabbing yourself, shooting yourself and jumping off a building all at the same time,” said Northwestern scientist and lead study author Marcus Peter. “You cannot survive.”
Anal Cancer More Deadly in Black Men
Al B. Benson III, MD, of the Robert H. Lurie Comprehensive Cancer Center of Northwestern University in Chicago, and Chair of the NCCN Clinical Practice Guidelines in Oncology Panels for Colon, Rectal, and Anal Cancers, stated: “This report from a large cohort provides critical observations that reinforce two important concerns. First, the incidence of anal cancer is increasing secondary to rising numbers of individuals with HPV infection and the association with HIV infection. Second, healthcare disparities across diseases—including cancer—are a major problem in the United States, particularly for African American males. As tragically noted from this SEER database assessment, it is also resulting in unacceptable outcomes. The authors provide insights as to the cause of disparities and methods to address the disparities with the hope that communities across the country will intervene to assist this vulnerable population.”
Lurie Cancer Center member, Shira Dinner, MD, Assistant Professor of Medicine in the Division of Hematology and Oncology at the Feinberg School of Medicine, is one of 10 investigators nationwide to receive a 2017 Cancer Clinical Investigator Team Leadership Award from the National Cancer Institute (NCI).
A new study finds that patients with double-hit lymphoma who received autologous stem cell transplantation saw no survival benefit, compared to patients who did not undergo the procedure. Read more >>
A team of scientists has demonstrated the mechanism by which ETO2-GLIS2, a gene fusion, promotes the development of an aggressive form of pediatric leukemia. The findings, published in Cancer Cell, also reveal an opportunity for the development of therapeutics.
The study was co-authored by John Crispino, PhD, the Robert I. Lurie, MD, and Lora S. Lurie Professor of Medicine in the Division of Hematology and Oncology.
Children with allergies to vaccines, and individuals with weak or compromised immune systems, rely on "herd immunity" for protection from disease. "Statistically, there are significant increases in vaccine-preventable diseases during modern times when the numbers of vaccinations in certain areas dropped," says Shikha Jain, M.D., a hematologist and oncologist at Chicago's Northwestern Memorial Hospital. In other words, when everyone else is vaccinated, it provides "indirect protection to those who are unable to receive the vaccine," she says. that survivors are living longer.
A new study has provided yet more evidence that survivors of endometrial cancer should be closely monitored for cardiovascular disease. These women are at higher risk for various long-term cardiovascular problems compared with their cancer-free counterparts, especially phlebitis and thrombophlebitis, pulmonary heart disease, hypotension, and atrial fibrillation.
In providing a rationale for their study, the research team from New York Presbyterian/Lawrence Hospital, Northwestern Medicine, and the Lurie Comprehensive Cancer Center, pointed to the “particularly concerning effect” posed by cancer therapy–related cardiac dysfunction now that survivors are living longer.