Northwestern University Feinberg School of Medicine

Department of Medicine

Hidayatullah G Munshi, MD

Hidayatullah G Munshi, MD

Associate Professor of Medicine (Hematology and Oncology)

Focus of Work

Bio

Pancreatic cancer remains the most lethal human malignancy because of early metastasis and lack of significant response to current therapies. Since human pancreatic tumors are associated with a pronounced fibrotic reaction, my lab has been interested in understanding how this fibrosis contributes to pancreatic cancer progression:

1. Understand how fibrosis regulates pancreatic cancer invasion and metastasis. We have evaluated the role of proteases in pancreatic cancer progression using in vitro...[Read full text]
Pancreatic cancer remains the most lethal human malignancy because of early metastasis and lack of significant response to current therapies. Since human pancreatic tumors are associated with a pronounced fibrotic reaction, my lab has been interested in understanding how this fibrosis contributes to pancreatic cancer progression:

1. Understand how fibrosis regulates pancreatic cancer invasion and metastasis. We have evaluated the role of proteases in pancreatic cancer progression using in vitro and in vivo models. Since epithelial-mesenchymal transition (EMT) contributes to cancer progression, we have also been examining the role of Snail and Slug transcription factors in pancreatic cancer progression using in vitro and in vivo models.

2. Understand how fibrosis contributes to treatment resistance in pancreatic cancer. My lab is also interested in understanding the role of the collagen microenvironment in treatment resistance. We have found that epigenetic changes induced by the collagen microenvironment contribute to resistance to chemotherapy. We have found that collagen microenvironment induces histone acetylation and that targeting “readers” of histone acetylation marks using BET inhibitors can limit growth of pancreatic cancer cells. My lab is currently evaluating BET inhibitors in mouse models of pancreatic cancer with the goal of eventually translating these inhibitors to pancreatic cancer patients.[Shorten text]

Keywords

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Education and Certification

  • MD: Harvard University (1996)
  • Residency: University of Washington Medical Center (1999)
  • Fellowship: University of Michigan Health System (2000)
  • Fellowship: Northwestern University, McGaw Medical Center (Northwestern Memorial Hospital) (2002)
  • Board Certification: Hematology, Internal Medicine, Medical Oncology

Contact

312/695-6180

Robert H Lurie Medical Research Center Room 3-117
303 E Superior
Chicago IL 60611