Northwestern University Feinberg School of Medicine

Department of Medicine

Manu  Jain, MD

Manu Jain, MD

Professor of Medicine (Pulmonary and Critical Care) and Pediatrics



McGaw Pavilion Suite M-300
240 E Huron
Chicago IL 60611

m-jain( at )

Hospital Affiliations

I am on the medical staff at the following Feinberg-affiliated hospital(s)

Education and Certification

MD: University of Chicago (1989)
Internship: University of Chicago Pritzker School of Medicine, Internal Medicine (1990)
Residency: Univ. of Chicago Hospital, Internal Medicine (1992)
Fellowship: University of Chicago, Pulmonary & Critical Care Medicine (1996)
Board Certification: Critical Care Medicine, Internal Medicine, Pulmonary Disease


Description of Interests

My primary research interest is in lung repair after acute injury with a focus on TGF-beta mediated signaling. We have identified mitochondrial generated reactive oxygen species as important in TGF-bête mediated gene expression and are working to identify novel therapeutic targets in this pathway. We are also interested in modulating the ubiquitin-proteosomal pathway as a therapeutic target for tissue fibrosis. I have a clinical translational interest in Cystic Fibrosis. I am the site co-PI for the CF Foundation sponsored clinical trial network, The Therapeutic Development Network. I am also interested in the CF outcomes, especially related to chronic infection with Pseudomonas aeruginosa.

Interests (Keywords)

Critical Care; Cystic Fibrosis; Fibrosis; Lungs, Breathing Problems; TGF-beta

Research and Publications

Northwestern Scholars

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Institutes and Centers

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