Northwestern University Feinberg School of Medicine

Department of Medicine

Focus of Work

Bio

My primary research interest is in lung repair after acute injury with a focus on TGF-beta mediated signaling. We have identified mitochondrial generated reactive oxygen species as important in TGF-bête mediated gene expression and are working to identify novel therapeutic targets in this pathway. We are also interested in modulating the ubiquitin-proteosomal pathway as a therapeutic target for tissue fibrosis.
I have a clinical translational interest in Cystic Fibrosis. I am the site co-PI fo...[Read full text]
My primary research interest is in lung repair after acute injury with a focus on TGF-beta mediated signaling. We have identified mitochondrial generated reactive oxygen species as important in TGF-bête mediated gene expression and are working to identify novel therapeutic targets in this pathway. We are also interested in modulating the ubiquitin-proteosomal pathway as a therapeutic target for tissue fibrosis.
I have a clinical translational interest in Cystic Fibrosis. I am the site co-PI for the CF Foundation sponsored clinical trial network, The Therapeutic Development Network. I am also interested in the CF outcomes, especially related to chronic infection with Pseudomonas aeruginosa.[Shorten text]

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Education and Certification

  • MD: University of Chicago (1989)
  • Internship: University of Chicago Pritzker School of Medicine, Internal Medicine (1990)
  • Residency: Univ. of Chicago Hospital, Internal Medicine (1992)
  • Fellowship: University of Chicago, Pulmonary & Critical Care Medicine (1996)
  • Board Certification: Critical Care Medicine, Internal Medicine, Pulmonary Disease