Northwestern University Feinberg School of Medicine

Department of Medicine

Marie-Pier  Tetreault, PhD

Marie-Pier Tetreault, PhD

Assistant Professor of Medicine (Gastroenterology and Hepatology)

Focus of Work

Bio

The Tetreault Lab uses novel mouse models and three-dimensional organotypic culture to delineate the reciprocal contributions of the epithelium and the microenvironment to inflammatory diseases of the gastrointestinal tract.

Our research program focuses on diseases of the esophagus, which are among the most common ailments in the United States and throughout the world, resulting in significant morbidity, mortality, and health care expenditures. Understanding the molecular mechanisms underlyin...[Read full text]
The Tetreault Lab uses novel mouse models and three-dimensional organotypic culture to delineate the reciprocal contributions of the epithelium and the microenvironment to inflammatory diseases of the gastrointestinal tract.

Our research program focuses on diseases of the esophagus, which are among the most common ailments in the United States and throughout the world, resulting in significant morbidity, mortality, and health care expenditures. Understanding the molecular mechanisms underlying esophageal disease pathogenesis is crucial and will lead to considerable improvements in the diagnosis and the treatment of esophageal cancer. Although alterations of the microenvironment have been described in esophageal diseases, such as esophageal cancer and esophagitis, our knowledge of the molecular mechanisms that mediate changes in the microenvironment and that regulate epithelial-stromal interactions in the context of esophageal cancer is still very limited.

Our research program focuses on two key inflammatory pathways: the IKKß/NFkB and STAT3 pathways. We employ novel in vitro and in vivo models and state-of-the-art methodology to define key factors regulating epithelial-epithelial and epithelial-stromal signaling in the esophagus. More specifically, our goal is to better understand:

1) How epithelial IKKß signaling regulates the balance between angiogenic and angiostatic factors, and how it affects the stromal microvasculature
2) How epithelial IKKß signaling contributes to the phenotypic heterogeneity of stromal fibroblasts
3) How epithelial IKKß signaling controls the recruitment of immune cells
4) The complex interplay existing between IKKß and STAT3 signaling pathways.

We expect that these investigations will uncover novel diagnostic and therapeutic targets for esophageal cancer.[Shorten text]

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Education and Certification

  • PhD: University of Sherbrooke, Cell Biology (2007)
  • Postdoctoral Fellowship: University of Pennsylvania, Gastroenterology (2011)

Contact

312-503-1915

Tarry Building Room 15-753
300 E Superior
Chicago IL 60611