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Northwestern University Feinberg School of Medicine
Sinus and Allergy Program

CRISP Publications

  1. Soliai MM, Kato A, Naughton KA, Norton JE, Klinger AI, Kern RC, Tan BK, Nicolae DL, Schleimer RP, Ober C  et al.  Epigenetic responses to rhinovirus exposure in airway epithelial cells are correlated with key transcriptional pathways in chronic rhinosinusitis.  Allergy  2023 Oct;78(10):2698-2711. doi:10.1111/all.15837
  2. Wang BF, Cao PP, Norton JE, Poposki JA, Klingler AI, Suh LA, Carter R, Huang JH, Bai J, Stevens WW  et al.  Evidence that oncostatin M synergizes with IL-4 signaling to induce TSLP expression in chronic rhinosinusitis with nasal polyps.  J Allergy Clin Immunol  2023 May;151(5):1379-1390.e11. doi:10.1016/j.jaci.2022.11.029
  3. Lal D, Brar T, Ramkumar SP, Li J, Kato A, Zhang L  Genetics and epigenetics of chronic rhinosinusitis.  J Allergy Clin Immunol  2023 Apr;151(4):848-868. doi:10.1016/j.jaci.2023.01.004
  4. Lin JS, Tan B, Yeh C, Kern R, Conley D, Welch K, Peters A, Smith S  Comparing the severity of chronic rhinosinusitis symptoms before versus during the COVID-19 pandemic.  Laryngoscope Investig Otolaryngol  2022 Dec;7(6):1704-1711. doi:10.1002/lio2.935
  5. Sakashita M, Takabayashi T, Imoto Y, Homma T, Yoshida K, Ogi K, Kimura Y, Kato A, Stevens WW, Smith SS  et al.  Retinoic acid promotes fibrinolysis and may regulate polyp formation.  J Allergy Clin Immunol  2022 Nov;150(5):1114-1124.e3. doi:10.1016/j.jaci.2022.05.021
  6. Cao PP, Wang BF, Norton JE, Suh LA, Carter RG, Stevens WW, Staudacher AG, Huang JH, Hulse KE, Peters AT  et al.  Studies on activation and regulation of the coagulation cascade in chronic rhinosinusitis with nasal polyps.  J Allergy Clin Immunol  2022 Aug;150(2):467-476.e1. doi:10.1016/j.jaci.2022.02.018
  7. Smith SS, Kim R, Douglas R  Is there a role for antibiotics in the treatment of chronic rhinosinusitis?  J Allergy Clin Immunol  2022 May;149(5):1504-1512. doi:10.1016/j.jaci.2022.02.004
  8. Poposki JA, Klingler AI, Stevens WW, Suh LA, Tan BK, Peters AT, Abdala-Valencia H, Grammer LC, Welch KC, Smith SS  et al.  Elevation of activated neutrophils in chronic rhinosinusitis with nasal polyps.  J Allergy Clin Immunol  2022 May;149(5):1666-1674. doi:10.1016/j.jaci.2021.11.023
  9. Kato A, Peters AT, Stevens WW, Schleimer RP, Tan BK, Kern RC  Endotypes of chronic rhinosinusitis: Relationships to disease phenotypes, pathogenesis, clinical findings, and treatment approaches.  Allergy  2022 Mar;77(3):812-826. doi:10.1111/all.15074
  10. Shintani-Smith S, Luong AU, Ramakrishnan VR, Tan BK, French DD, Kern RC  Acute invasive fungal sinusitis: Epidemiology and outcomes in the United States.  Int Forum Allergy Rhinol  2022 Feb;12(2):233-236. doi:10.1002/alr.22896
  11. Soliai MM, Kato A, Helling BA, Stanhope CT, Norton JE, Naughton KA, Klinger AI, Thompson EE, Clay SM, Kim S  et al.  Multi-omics colocalization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus.  Genome Med  2021 Oct 10;13(1):157. pii:157
  12. Peters AT, Bose S, Guo A, Li N, Benjamin M, Prickett M, Villareal RS, Yang A, Kato A, Kern RC  et al.  Prevalence of Bronchiectasis in Patients with Chronic Rhinosinusitis in a Tertiary Care Center.  J Allergy Clin Immunol Pract  2021 Aug;9(8):3188-3195.e2. doi:10.1016/j.jaip.2021.04.054
  13. Stevens WW, Staudacher AG, Hulse KE, Poposki JA, Kato A, Carter RG, Suh LA, Norton JE, Huang JH, Peters AT  et al.  Studies of the role of basophils in aspirin-exacerbated respiratory disease pathogenesis.  J Allergy Clin Immunol  2021 Aug;148(2):439-449.e5. doi:10.1016/j.jaci.2021.02.045
  14. McKennan C, Naughton K, Stanhope C, Kattan M, O'Connor GT, Sandel MT, Visness CM, Wood RA, Bacharier LB, Beigelman A  et al.  Longitudinal data reveal strong genetic and weak non-genetic components of ethnicity-dependent blood DNA methylation levels.  Epigenetics  2021 Jun;16(6):662-676. doi:10.1080/15592294.2020.1817290
  15. Soliai M, Sundaresan AS, Morin A, Hirsch AG, Stanhope C, Kuiper J, Schwartz BS, Ober C, Pinto JM  Two-stage genome-wide association study of chronic rhinosinusitis and disease subphenotypes highlights mucosal immunity contributing to risk.  Int Forum Allergy Rhinol  2021 Apr;11(4):814-817. doi:10.1002/alr.22731
  16. Klingler AI, Stevens WW, Tan BK, Peters AT, Poposki JA, Grammer LC, Welch KC, Smith SS, Conley DB, Kern RC  et al.  Mechanisms and biomarkers of inflammatory endotypes in chronic rhinosinusitis without nasal polyps.  J Allergy Clin Immunol  2021 Apr;147(4):1306-1317. doi:10.1016/j.jaci.2020.11.037
  17. Stevens WW, Kato A  Group 2 innate lymphoid cells in nasal polyposis.  Ann Allergy Asthma Immunol  2021 Feb;126(2):110-117. doi:10.1016/j.anai.2020.08.001
  18. Stevens WW, Staudacher AG, Hulse KE, Carter RG, Winter DR, Abdala-Valencia H, Kato A, Suh L, Norton JE, Huang JH  et al.  Activation of the 15-lipoxygenase pathway in aspirin-exacerbated respiratory disease.  J Allergy Clin Immunol  2021 Feb;147(2):600-612. doi:10.1016/j.jaci.2020.04.031
  19. Takahashi T, Kato A, Suh LA, Carter RG, Stevens WW, Price CPE, Norton JE, Weibman AR, Harris KE, Peters AT  et al.  Integrin β6 microparticles in nasal lavage fluids; potential new biomarkers for basal cell activation in chronic rhinosinusitis.  Allergy  2020 Dec;75(12):3261-3264. doi:10.1111/all.14419
  20. Staudacher AG, Peters AT, Carter RG, Welch KC, Stevens WW  Decreased nasal polyp eosinophils but increased mast cells in a patient with aspirin-exacerbated respiratory disease treated with reslizumab.  Ann Allergy Asthma Immunol  2020 Oct;125(4):490-493.e2. doi:10.1016/j.anai.2020.06.043
  21. Ghadersohi S, Price CPE, Jensen SE, Beaumont JL, Kern RC, Conley DB, Welch KC, Peters AT, Grammer LC, Stevens WW  et al.  Development and Preliminary Validation of a New Patient-Reported Outcome Measure for Chronic Rhinosinusitis (CRS-PRO).  J Allergy Clin Immunol Pract  2020;8(7):2341-2350.e1. doi:10.1016/j.jaip.2020.04.048
  22. Kuiper JR, Hirsch AG, Bandeen-Roche K, Sundaresan AS, Tan BK, Kern RC, Schleimer RP, Schwartz BS  A new approach to categorization of radiologic inflammation in chronic rhinosinusitis.  PLoS One  2020;15(6):e0235432. pii:e0235432
  23. Kwah JH, Somani SN, Stevens WW, Kern RC, Smith SS, Welch KC, Conley DB, Tan BK, Grammer LC, Yang A  et al.  Clinical factors associated with acute exacerbations of chronic rhinosinusitis.  J Allergy Clin Immunol  2020 Jun;145(6):1598-1605. doi:10.1016/j.jaci.2020.01.023
  24. Kochhar A, Zhang Y, Fisher L, Byrne P, Smith SS, Ference EH  Analysis of the operative utilization of concurrent rhinoplasty and endoscopic sinus surgery.  Laryngoscope  2020 May;130(5):E311-E319. doi:10.1002/lary.28031
  25. Hirsch AG, Nordberg C, Bandeen-Roche K, Tan BK, Schleimer RP, Kern RC, Sundaresan A, Pinto JM, Kennedy TL, Greene JS  et al.  Radiologic sinus inflammation and symptoms of chronic rhinosinusitis in a population-based sample.  Allergy  2020 Apr;75(4):911-920. doi:10.1111/all.14106
  26. Ogasawara N, Poposki JA, Klingler AI, Tan BK, Hulse KE, Stevens WW, Peters AT, Grammer LC, Welch KC, Smith SS  et al.  Role of RANK-L as a potential inducer of ILC2-mediated type 2 inflammation in chronic rhinosinusitis with nasal polyps.  Mucosal Immunol  2020 Jan;13(1):86-95. doi:10.1038/s41385-019-0215-8
  27. Ogasawara N, Poposki JA, Klingler AI, Tan BK, Hulse KE, Stevens WW, Peters AT, Grammer LC, Welch KC, Smith SS  et al.  TNF induces production of type 2 cytokines in human group 2 innate lymphoid cells.  J Allergy Clin Immunol  2020 Jan;145(1):437-440.e8. doi:10.1016/j.jaci.2019.09.001
  28. Somani SN, Kwah JH, Yeh C, Conley DB, Grammer LC, Kern RC, Prickett M, Schleimer RP, Smith SS, Stevens WW  et al.  Prevalence and characterization of chronic rhinosinusitis in patients with non-cystic fibrosis bronchiectasis at a tertiary care center in the United States.  Int Forum Allergy Rhinol  2019 Dec;9(12):1424-1429. doi:10.1002/alr.22436
  29. Imoto Y, Kato A, Takabayashi T, Stevens W, Norton JE, Suh LA, Carter RG, Weibman AR, Hulse KE, Harris KE  et al.  Increased thrombin-activatable fibrinolysis inhibitor levels in patients with chronic rhinosinusitis with nasal polyps.  J Allergy Clin Immunol  2019 Dec;144(6):1566-1574.e6. doi:10.1016/j.jaci.2019.08.040
  30. Stevens WW, Peters AT, Tan BK, Klingler AI, Poposki JA, Hulse KE, Grammer LC, Welch KC, Smith SS, Conley DB  et al.  Associations Between Inflammatory Endotypes and Clinical Presentations in Chronic Rhinosinusitis.  J Allergy Clin Immunol Pract  2019;7(8):2812-2820.e3. doi:10.1016/j.jaip.2019.05.009
  31. Kuiper JR, Hirsch AG, Bandeen-Roche K, Sundaresan AS, Tan BK, Kern RC, Schleimer RP, Schwartz BS  Workplace Indirect Cost Impacts of Nasal and Sinus Symptoms and Related Conditions.  J Occup Environ Med  2019 Aug;61(8):e333-e339. doi:10.1097/JOM.0000000000001636
  32. Kato A  Group 2 Innate Lymphoid Cells in Airway Diseases.  Chest  2019 Jul;156(1):141-149. doi:10.1016/j.chest.2019.04.101
  33. Takabayashi T, Tanaka Y, Susuki D, Yoshida K, Tomita K, Sakashita M, Imoto Y, Kato Y, Narita N, Nakayama T  et al.  Increased expression of L-plastin in nasal polyp of patients with nonsteroidal anti-inflammatory drug-exacerbated respiratory disease.  Allergy  2019 Jul;74(7):1307-1316. doi:10.1111/all.13677
  34. Khanwalkar AR, Shen J, Kern RC, Welch KC, Smith SS, Tan BK, Conley DB  Utilization of a novel interactive mobile health platform to evaluate functional outcomes and pain following septoplasty and functional endoscopic sinus surgery.  Int Forum Allergy Rhinol  2019 Apr;9(4):345-351. doi:10.1002/alr.22273
  35. Dilger AE, Peters AT, Wunderink RG, Tan BK, Kern RC, Conley DB, Welch KC, Holl JL, Smith SS  Procalcitonin as a Biomarker in Rhinosinusitis: A Systematic Review.  Am J Rhinol Allergy  2019 Mar;33(2):103-112. doi:10.1177/1945892418810293
  36. Kim KW, Ober C  Lessons Learned From GWAS of Asthma.  Allergy Asthma Immunol Res  2019 Mar;11(2):170-187. doi:10.4168/aair.2019.11.2.170
  37. Benjamin MR, Stevens WW, Li N, Bose S, Grammer LC, Kern RC, Tan BK, Conley DB, Smith SS, Welch KC  et al.  Clinical Characteristics of Patients with Chronic Rhinosinusitis without Nasal Polyps in an Academic Setting.  J Allergy Clin Immunol Pract  2019 Mar;7(3):1010-1016. doi:10.1016/j.jaip.2018.10.014
  38. Daya M, Rafaels N, Brunetti TM, Chavan S, Levin AM, Shetty A, Gignoux CR, Boorgula MP, Wojcik G, Campbell M  et al.  Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations.  Nat Commun  2019 Feb 20;10(1):880. pii:880
  39. Gupta RS, Warren CM, Smith BM, Jiang J, Blumenstock JA, Davis MM, Schleimer RP, Nadeau KC  Prevalence and Severity of Food Allergies Among US Adults.  JAMA Netw Open  2019 Jan 04;2(1):e185630. pii:e185630
  40. Cao PP, Wang ZC, Schleimer RP, Liu Z  Pathophysiologic mechanisms of chronic rhinosinusitis and their roles in emerging disease endotypes.  Ann Allergy Asthma Immunol  2019 Jan;122(1):33-40. doi:10.1016/j.anai.2018.10.014