The Division of Gastroenterology and Hepatology's research activities reflect the diversity of faculty interests and clinical areas of expertise, as well as continues to transform the field of gastroenterology. Divisional faculty members conduct clinical studies, basic science, and translational research that encompass many subspecialties of gastroenterology and hepatology and include:
- Esophageal disease
- Swallowing disorders
- Pancreatic/biliary disease
- Liver disease and management of liver transplantation,
- General gastrointestinal disease – including colorectal cancer screening, weight loss, high-risk colon cancer prevention ( including gastrointestinal genetic disorders)
- Irritable bowel syndrome and related health psychology services
- Inflammatory bowel disease
- Nutrition/intestinal absorption disorders.
The division’s combined research activities result annually in approximately $10 million in direct costs, which are supported by NIH, industry/technology or foundation grants. A good number of our clinical fellows are actively engaged in research projects supported by NIH-funded training grants.
Research Centers and Programs
Discover the connections between our division and many of the innovative research centers throughout Northwestern Medicine
Learn more about the lab work within our division.
The Green Lab investigates the genetics and molecular biology of cholestatic liver diseases and fatty liver disorders. The major current focus is on the role of ER Stress and the Unfolded Protein Response (UPR) in the pathogenesis of these hepatic diseases.
The Henkel lab studies hepatic lipid metabolism and mechanisms of liver injury related to fatty liver disease.
The Keefer Lab investigates psychosocial factors that affect patient’s symptom experience across the spectrum of digestive disease and develops and validates behavioral self-management tools in order to improve health outcomes.
The Pandolfino Lab investigates all aspects of esophageal dysfunction. Primary foci include pathophysiological mechanisms of symptom generation in dysphagia as well as symptom perception in patients with GERD symptoms.
The Tetreault Lab uses novel mouse models and three-dimensional organotypic culture to delineate the reciprocal contributions of the epithelium and the microenvironment to inflammatory diseases of the gastrointestinal tract.