Molecular Mechanisms of Lung Disease

The inaugural Simpson Querrey Lung Institute for Translational Sciences (SQLIFTS) at Northwestern University and the Institute for Lung Health and Immunity (LHI), Helmholz-Munich joint conference titled “Molecular Mechanisms of Lung Disease” will be held on September 21st and 22nd at the Hyatt Centric Hotel located at 633 N St Clair St, Chicago, IL 60611.

Registration is required to attend this two-day conference. The deadline to register is Monday, September 18, 2023. Online registration is located here. There is no charge for registration.

Symposium Organizers

This conference is organized by G.R. Scott Budinger, MD, Navdeep S. Chandel, PhD, Roxana Maria Wasnick, MD, PhD and Ali Onder Yildirim, PhD.

Program Description

This program will highlight important advances in the pathobiology of lung disease and repair with an emphasis on pathways that might serve as new targets for therapy.

Speakers

	Janelle Ayres, PhD Salk Institute
	Scott Budinger, MD Northwestern University
	Navdeep Chandel, PhD Northwestern University
	Ralph DeBerardinis, MD, PhD UT Southwestern
	Scott Dixon, PhD Stanford University
	William Janssen, MD University of Colorado
	Tereza Martinu, MD University of Toronto
	Kim Newton, PhD Genentech
	Tien Peng, MD University of California at San Francisco
	Francesca Polverino, MD, PharmD Baylor College of Medicine
	Jennifer Sucre, MD Vanderbilt University
	Xin Sun, PhD University of California at San Diego
	Ali Onder Yildirim, PhD Helmholtz Munich

Registration

Registration is required. Please click here to register for this meeting. Seating is limited!

If you have problems accessing the link, please email Sean Campbell at seancampbell@northwestern.edu.

Schedule

PDF Version Available Here!

Day 1: Thursday, September 21st

8:30 - 8:50am

Breakfast

8:50-9:05am

Welcome and Introduction
GR Scott Budinger, MD
Chief of Pulmonary and Critical Care in the Department of Medicine
Ernest S. Bazley Professor of Airway Diseases
Northwestern University, Feinberg School of Medicine

Morning Session

9:05-9:10am

Session Introduction
Session Chair: Cara Gottardi, PhD
Associate Professor
Northwestern University, Feinberg School of Medicine

9:10-9:40am

Considering the Lung as a Sensory Organ
Xin Sun, PhD
Professor, Department of Pediatrics and Cell and Developmental Biology
University of California San Diego

25-min talk, 5-min discussion

9:40-10:10am

The 4-Dimensional Fabric of the Lung: Development and Regeneration Across Space and Time
Jennifer Sucre, MD
Assistant Professor of Pediatrics and Cell and Developmental Biology
Vanderbilt University School of Medicine

25-min talk, 5-min discussion

10:10-10:30am

Coffee Break

10:30-10:50am

Machine Learning Identifies Distinct Clinical States in Patients with Suspected Pneumonia Requiring Mechanical Ventilation
Catherine Gao, MD
NRSA Post-doctoral Fellow
Northwestern University, Feinberg School of Medicine

15-min talk, 5-min discussion

10:50-11:10am

Myeloid Contributions to Pulmonary Fibrosis Progression
Isis Fernandez, MD, PhD
Research Area Leader: Immunometabolic Reprogramming
Institute for Lung Health and Immunity, Helmholtz-Munich
Fellow, Division of Pulmonary Medicine
University Hospital Großhadern
Ludwig-Maximilian University, Munich

15-min talk, 5-min discussion

11:10-11:30am

Activation of the Integrated Stress Response in Alveolar Type 2 Cells Leads to Spontaneous Pulmonary Fibrosis and Impaired Alveolar Epithelial Differentiation
Mariana Maciel Herrerias, PhD
Post-doctoral Research Fellow
Northwestern University, Feinberg School of Medicine

15-min talk, 5-min discussion

11:30-11:50am

Understanding and Utilizing the Immunomechanistic Pathway of Primary Graft Dysfunction after Lung Transplantation
Melissa L Querrey, MD, PhD
Physician Scientist Training Program
McGaw Medical Center of Northwestern University

15-min talk, 5-min discussion

11:50-12:20pm

Mechanisms of chronic lung allograft rejection: implications for improved diagnostics and therapeutics in lung transplantation
Tereza Martinu, MD
Associate Professor of Medicine
Clinician-Scientist
University Health Network, University of Toronto

25-min talk, 5-min discussion

12:20-3:00pm

Lunch and Poster Session

Afternoon Session

3:00-3:05pm

Session Introduction

Session Chair: Roxana Wasnick, MD, PhD
Science Manager
Institute for Lung Health and Immunity, Helmholtz Munich

3:05-3:35pm

Fibroblast's Role in Inflammation and Aging (Inflammaging) in the Lung
Tien Peng, MD
Associate Professor of Medicine
Department of Medicine, Bakar Aging Research Institute, Bakar ImmunoX Initiative
University of California, San Francisco

25-min talk, 5-min discussion

3:35-4:05pm

Immune and Molecular Mechanisms of COPD
Francesca Polverino, MD, PhD
Lester and Sue Smith Associate Professor of Medicine
Baylor College of Medicine

25-min talk, 5-min discussion

4:05-4:25pm

Decoding Myeloid Cell Heterogeneity in the COPD lung: Lessons From Multi-Omics Technologies
Theodoros Kapellos, PhD
Junior Group Leader
Institute for Lung Health and Immunity, Helmholtz Munich, Germany

15-min talk, 5-min discussion

4:25-4:45pm

Novel Immune-Therapeutic Targets in COPD
Thomas Conlon, PhD
Group Leader
Institute for Lung Health and Immunity, Helmholtz-Munich, Germany

15-min talk, 5-min discussion

4:45-5:00pm

Closing Remarks
GR Scott Budinger, MD
Chief of Pulmonary and Critical Care in the Department of Medicine
Ernest S. Bazley Professor of Airway Diseases
Northwestern University, Feinberg School of Medicine

5:00-6:30pm

Reception

Day 2: Friday, September 22nd
Morning Session
8:30-9:00am	Breakfast
9:00-9:15am	Welcome and Introduction Ali Onder Yildirim, PhD Director of Institute for Lung Health and Immunity, Comprehensive Pneumology Center (CPC) Helmholtz Zentrum Muenchen
9:15-9:20am	Session Introduction Session Chair: Victor Thannickal, MD Chair, John W. Deming Department of Medicine Professor of Medicine Tulane University School of Medicine
9:20-9:50am	Macrophage Heterogeneity in Acute Lung Injury William J Janssen, MD Professor of Medicine and Section Head for Critical Care National Jewish Health 25-min talk, 5-min discussion
9:50-10:20am	Targeted Alveolar Regeneration with Frizzled-specific Agonists Kim Newton, PhD Distinguished Scientist, Physiological Chemistry Department Genentech 25-min talk, 5-min discussion
10:20-10:40am	Coffee Break
10:40-11:00am	Impact of Cellular Senescence and Inflammaging on Alveolar Regeneration Programs Mareike Lehmann, PhD Institute for Lung Health and Immunity, Helmholtz Munich, Germany Institute for Lung Research, Philipps-University Marburg, Germany 15-min talk, 5-min discussion
11:00-11:20am	Chronic Lung Allograft Dysfunction: Phenotyping and Translational Research Jürgen Behr, MD Professor of Internal Medicine – Pneumology, Ludwig-Maximilians University Director of the Department of Internal Medicine V, Ludwig-Maximilians University Hospital 15-min talk, 5-min discussion
11:20-11:40am	Monocyte-derived inflammation in pediatric viral pneumonia Bria Coates, MD Assistant Professor Department of Pediatrics (Critical Care) Northwestern University, Feinberg School of Medicine 15-min talk, 5-min discussion
11:40-12:00pm	Single-cell RNA Sequencing Reveals Dynamics of Pulmonary Inflammation After Nanomaterial Inhalation Driven by Material Specific Cellular Perturbations Tobias Stöger, PhD Research Area Leader: Environmental Barrier Immunity Institute for Lung Health and Immunity, Helmholtz Munich, Germany 15-min talk, 5-min discussion
12:00-1:00pm	Lunch
Afternoon Session
1:00-1:05pm	Session Introduction Session Chair: Navdeep Chandel, PhD Professor Northwestern University, Feinberg School of Medicine
1:05-1:55pm	Keynote Speaker: Metabolism and Cancer Progression in Patients Ralph DeBerardinis, MD, PhD Investigator, Howard Hughes Medical Institute and Professor, Children’s Research Institute University of Texas Southwestern Medical Center 40-min talk, 10-min discussion
1:55-2:25pm	Host-pathogen interactions: Harnessing co-evolution to treat disease Janelle Ayres, PhD Professor Salk Institute 25-min talk, 5-min discussion
2:25-2:55pm	Understanding and Modulating Ferroptosis in Lung Cancer Scott Dixon, PhD Associate Professor, Department of Biology Stanford University 25-min talk, 5-min discussion
2:55-3:15pm	Coffee Break
3:15-3:45pm	Ferroptosis in Lung Transplantation Aicha Jeridi, PhD Postdoctoral Fellow Institute for Lung Health and Immunity, Helmholtz Munich, Germany 15-min talk, 5-min discussion
3:45-4:05pm	AMPK is Required for Treg Cell Function Under Metabolic Stress During Viral Pneumonia Manuel A Torres Acosta, PhD Candidate Graduate Student, Medical Scientist Training Program Northwestern University, Feinberg School of Medicine 15-min talk, 5-min discussion
4:05-4:25pm	Mitochondrial-dependent ISR Controls Lung Epithelial Cell Fate SeungHye Han, MD, MPH Assistant Professor Northwestern University, Feinberg School of Medicine 15-min talk, 5-min discussion
4:25-4:45pm	Spatial Assessment of Metabolism Shawn Davidson, PhD Assistant Professor Northwestern University, Feinberg School of Medicine 15-min talk, 5-min discussion
4:45-5:00pm	Closing Remarks GR Scott Budinger, MD Chief of Pulmonary and Critical Care in the Department of Medicine Ernest S. Bazley Professor of Airway Diseases Northwestern University, Feinberg School of Medicine Ali Onder Yildirim, PhD Director of Institute for Lung Health and Immunity, Comprehensive Pneumology Center (CPC) Helmholtz Zentrum Muenchen

Accommodations

There are several hotels that are within walking distance of the conference venue:

AC Hotel by Marriott, 630 North Rush, Chicago, IL 60611

Aloft Chicago Mag Mile, 243 East Ontario, Chicago, IL 60611

Courtyard by Marriott, 165 East Ontario, Chicago, IL 60611

DoubleTree by Hilton, 300 East Ohio, Chicago, IL 60611

Embassy Suites, 511 North Columbus Drive, Chicago, IL 60611

Embassy Suites, 600 North State Street, IL 60654

Hampton Inn, 160 East Huron, Chicago, IL 60611

Homewood Suites, 152 East Huron, Chicago, IL 60611

Hyatt Centric Chicago, 633 North St. Clair, Chicago, IL 60611

Omni Hotel, 676 North Michigan Avenue, Chicago, IL 60611

W Chicago, 644 North Lake Shore Drive, Chicago, IL 60611

Warwick Allerton, 701 North Michigan Avenue, Chicago, IL 60611

Public Transportation

During rush hour (7-9 AM and 4-6 PM) or inclement weather: The Chicago Transit Authority (CTA) offers train service to/from both O’Hare and Midway airports and can be the most reliable way to reach our campus.

During non-peak travel times: Taxis or ride sharing services are also good options to travel to our campus.

CTA Service

You will need a Ventra Card to use the train and bus in Chicago. You can purchase a card online or at any CTA station. The fare is $5 for the train from O’Hare and $0.25 for the bus transfer (used within 2 hours of original fare).

Route from O'Hare

From O’Hare International Airport Terminals 1, 2, or 3, follow signs that say “CTA Trains” or “Trains to City” which will take you to the O’Hare Blue Line station on the lower level.
Take the Blue Line train to the Clark/Lake station to transfer to the Red Line. From the Red Line station at Lake, take the Red Line train heading north to the Howard station. Get off at the Chicago station (second stop). Go east on Chicago Avenue to Michigan Avenue, then head south to the street of your hotel. (Superior, Huron, or Erie Street, ~0.3 miles)

From O’Hare International Airport Terminals 1, 2, or 3, follow signs that say “CTA Trains” or “Trains to City” which will take you to the O’Hare Blue Line station on the lower level.
Take the Blue Line train and get off at the Chicago station. Take the CTA Bus #66 east to Navy Pier. Get off at the Superior, Huron, or Erie stop, depending on your hotel.

Route from Midway

From Midway International Airport, follow signs that say “CTA Trains” or “Trains to City” which will take you to the Midway Orange Line station located on the east side of the airport.
Take the Orange Line train to the State/Lake station to transfer to the Red Line. From the Red Line station at Lake, take the Red Line train heading north to the Howard station. Get off at the Chicago station (second stop). Go east on Chicago Avenue to Michigan Avenue, then head south to the street of your hotel. (Superior, Huron, or Erie Street, ~0.3 miles)

Campus Shuttle Bus Service

The Intercampus Shuttle runs between the Chicago and Evanston campus on Monday through Friday.

Campus Map

Campus Map (pdf)

Interactive Map (Google Maps)