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Northwestern University Feinberg School of Medicine
Northwestern Medicine Asthma & COPD Program

Publications

  1. Bailey JI, Puritz CH, Senkow KJ, Markov NS, Diaz E, Jonasson E, Yu Z, Swaminathan S, Lu Z, Fenske S  et al.  Profibrotic monocyte-derived alveolar macrophages are expanded in patients with persistent respiratory symptoms and radiographic abnormalities after COVID-19.  Nat Immunol  2024 Oct 04;. doi:10.1038/s41590-024-01975-x
  2. Perry AS, Amancherla K, Huang X, Lance ML, Farber-Eger E, Gajjar P, Amrute J, Stolze L, Zhao S, Sheng Q  et al.  Clinical-transcriptional prioritization of the circulating proteome in human heart failure.  Cell Rep Med  2024 Sep 17;5(9):101704. doi:10.1016/j.xcrm.2024.101704
  3. Liu GY, Perry AS, Washko GR, Farber-Eger E, Colangelo LA, Sheng Q, Wells Q, Huang X, Thyagarajan B, Guan W  et al.  Proteomic Risk Score of Increased Respiratory Susceptibility: A Multi-Cohort Study.  Am J Respir Crit Care Med  2024 Sep 10;. doi:10.1164/rccm.202403-0613OC
  4. Eckhardt CM, Balte P, Morris JE, Bhatt SP, Couper D, Fetterman J, Freedman N, Jacobs DR, Hou L, Kalhan R  et al.  Non-cigarette tobacco products, aryl-hydrocarbon receptor repressor gene methylation and smoking-related health outcomes.  Thorax  2024 Jul 20;. pii:thorax-2023-220731
  5. Perry AS, Zhang K, Murthy VL, Choi B, Zhao S, Gajjar P, Colangelo LA, Hou L, Rice MB, Carr JJ  et al.  Proteomics, Human Environmental Exposure, and Cardiometabolic Risk.  Circ Res  2024 Jun 21;135(1):138-154. doi:10.1161/CIRCRESAHA.124.324559
  6. Perry AS, Farber-Eger E, Gonzales T, Tanaka T, Robbins JM, Murthy VL, Stolze LK, Zhao S, Huang S, Colangelo LA  et al.  Proteomic analysis of cardiorespiratory fitness for prediction of mortality and multisystem disease risks.  Nat Med  2024 Jun;30(6):1711-1721. doi:10.1038/s41591-024-03039-x
  7. Abdalla M, Elalami R, Cho MH, O'Connor GT, Rice M, Horowitz M, Akhoundi N, Yen A, Kalhan R, Diaz AA  Airway Mucus Plugs in Community-Living Adults: A Study Protocol.  medRxiv  2024 May 16;. pii:2024.05.15.24307439
  8. Choi B, Liu GY, Sheng Q, Amancherla K, Perry A, Huang X, San José Estépar R, Ash SY, Guan W, Jacobs DR  et al.  Proteomic Biomarkers of Quantitative Interstitial Abnormalities in COPDGene and CARDIA Lung Study.  Am J Respir Crit Care Med  2024 May 01;209(9):1091-1100. doi:10.1164/rccm.202307-1129OC
  9. Jackson MK, Choi Y, Eisenberg E, Hanson C, Wang A, Wang JG, Washko GR, Ash S, Estepar RSJ, Liu G  et al.  A Plant-Centered Diet is Inversely Associated With Radiographic Emphysema: Findings from the CARDIA Lung Study.  Chronic Obstr Pulm Dis  2024 Mar 26;11(2):164-173. doi:10.15326/jcopdf.2023.0437
  10. Ash S, Doyle TJ, Choi B, San Jose Estepar R, Castro V, Enzer N, Kalhan R, Liu G, Bowler R, Wilson DO  et al.  Utility of peripheral protein biomarkers for the prediction of incident interstitial features: a multicentre retrospective cohort study.  BMJ Open Respir Res  2024 Mar 14;11(1). pii:e002219
  11. Wharton RC, Wang JG, Choi Y, Eisenberg E, Jackson MK, Hanson C, Liu B, Washko GR, Kalhan R, Jacobs DR  et al.  Associations of a plant-centered diet and lung function across early to mid-adulthood: The CARDIA Lung Study.  Respir Res  2024 Mar 11;25(1):122. pii:122
  12. Criner GJ, Mallea JM, Abu-Hijleh M, Sachdeva A, Kalhan R, Hergott CA, Lazarus DR, Mularski RA, Calero K, Reed MF  et al.  Sustained Clinical Benefits of Spiration Valve System in Patients with Severe Emphysema: 24-Month Follow-Up of EMPROVE.  Ann Am Thorac Soc  2024 Feb;21(2):251-260. doi:10.1513/AnnalsATS.202306-520OC
  13. Wade RC, Ling SX, Helgeson ES, Voelker H, Labaki WW, Meza D, O'Corragain O, So JY, Criner GJ, Han MK  et al.  Associations Between Coronary Artery Calcium Score and Exacerbation Risk in BLOCK-COPD.  Chronic Obstr Pulm Dis  2024 Jan 25;11(1):101-105. doi:10.15326/jcopdf.2023.0423
  14. Abdalla M, Elalami R, Cho MH, O'Connor GT, Rice M, Horowitz M, Akhoundi N, Yen A, Kalhan R, Diaz AA  Airway Mucus Plugs in Community-Living Adults: A Study Protocol.  J Clin Exp Pathol  2024;14(3). pii:492
  15. Mathew AR, Avery EF, Cox C, Nwanah P, Kalhan R, Hitsman B, Powell LH  Development of a targeted behavioral treatment for smoking cessation among individuals with Chronic Obstructive Pulmonary Disease.  J Behav Med  2023 Dec;46(6):1010-1022. doi:10.1007/s10865-023-00411-z
  16. Kaminsky DA, He J, Henderson R, Dixon AE, Irvin CG, Mastronarde J, Smith LJ, Sugar EA, Wise RA, Holbrook JT  Bronchodilator response does not associate with asthma control or symptom burden among patients with poorly controlled asthma.  Respir Med  2023 Nov;218:107375. doi:10.1016/j.rmed.2023.107375
  17. Patchen BK, Balte P, Bartz TM, Barr RG, Fornage M, Graff M, Jacobs DR, Kalhan R, Lemaitre RN, O'Connor G  et al.  Investigating Associations of Omega-3 Fatty Acids, Lung Function Decline, and Airway Obstruction.  Am J Respir Crit Care Med  2023 Oct 15;208(8):846-857. doi:10.1164/rccm.202301-0074OC
  18. Liu GY, Colangelo LA, San Jose Estepar R, Esposito AJ, Ash SY, Choi B, Jacobs DR, Carnethon MR, Washko GR, Kalhan R  Low-Normal FVC Trajectory Starting in Early Adulthood and Risk of Future Interstitial Abnormalities.  Am J Respir Crit Care Med  2023 Oct 01;208(7):816-818. doi:10.1164/rccm.202304-0771LE
  19. Smith LJ  Postbronchodilator Reference Values: Should They Be the Norm?  Am J Respir Crit Care Med  2023 Aug 15;208(4):356-357. doi:10.1164/rccm.202306-1082ED
  20. Synn AJ, Menson KE, Carnethon MR, Kalhan R, Sugar EA, Washko GR, Wise RA, Eakin MN  "It's a cause I believe in": factors motivating participation and engagement in longitudinal, respiratory-focused research studies.  BMC Pulm Med  2023 Aug 04;23(1):285. pii:285
  21. Polverino F, Kalhan R  Leveraging Omics to Predict Chronic Obstructive Pulmonary Disease Exacerbations: The "Immunome".  Am J Respir Crit Care Med  2023 Aug 01;208(3):220-222. doi:10.1164/rccm.202306-0978ED
  22. Joyce BT, Chen X, Gao T, Zheng Y, Nannini DR, Liu L, Henkle BE, Kalhan R, Washko G, Kunisaki KM  et al.  Associations between GrimAge acceleration and pulmonary function in the Coronary Artery Risk Development in Young Adults (CARDIA) study.  Epigenomics  2023 Jul;15(13):693-703. doi:10.2217/epi-2023-0164
  23. Sharma R, Tiwari A, Kho AT, Wang AL, Srivastava U, Piparia S, Desai B, Wong R, Celedón JC, Peters SP  et al.  Circulating MicroRNAs associated with Bronchodilator Response in Childhood Asthma.  Res Sq  2023 Jun 29;. pii:rs.3.rs-3101724
  24. Liu GY, Colangelo LA, Ash SY, San Jose Estepar R, Jacobs DR, Thyagarajan B, Wells JM, Putman RK, Choi B, Stevenson CS  et al.  Computed tomography measure of lung injury and future interstitial features: the CARDIA Lung Study.  ERJ Open Res  2023 May;9(3). pii:00004-2023
  25. Bailey J, Lavelle B, Miller J, Jimenez M, Lim PH, Orban ZS, Clark JR, Tomar R, Ludwig A, Ali ST  et al.  Multidisciplinary Center Care for Long COVID Syndrome-A Retrospective Cohort Study.  Am J Med  2023 May 22;. pii:S0002-9343(23)00328-5
  26. Wharton R, Wang JG, Choi Y, Eisenberg E, Jackson MK, Hanson C, Liu B, Washko GR, Kalhan R, Jacobs DR  et al.  Associations of a Plant-centered Diet and Lung Function Decline across Early to Mid-Adulthood: The CARDIA Lung Study.  Res Sq  2023 Apr 26;. pii:rs.3.rs-2845326
  27. Dransfield M, Kalhan R, Stolz D  Pushing (for) GOLD.  Eur Respir J  2023 Apr;61(4). pii:2300366
  28. Dixon AE, Que LG, Kalhan R, Dransfield MT, Rogers L, Gerald LB, Kraft M, Krishnan JA, Johnson O, Hazucha H  et al.  Roflumilast May Increase Risk of Exacerbations When Used to Treat Poorly Controlled Asthma in People with Obesity.  Ann Am Thorac Soc  2023 Feb;20(2):206-214. doi:10.1513/AnnalsATS.202204-368OC
  29. Patchen BK, Balte P, Bartz TM, Barr RG, Fornage M, Graff M, Jacobs DR, Kalhan R, Lemaitre RN, O'Connor G  et al.  Investigating associations of omega-3 fatty acids, lung function decline, and airway obstruction.  medRxiv  2023 Jan 18;. pii:2023.01.18.23284671
  30. Choi B, Adan N, Doyle TJ, San José Estépar R, Harmouche R, Humphries SM, Moll M, Cho MH, Putman RK, Hunninghake GM  et al.  Quantitative Interstitial Abnormality Progression and Outcomes in the Genetic Epidemiology of COPD and Pittsburgh Lung Screening Study Cohorts.  Chest  2023 Jan;163(1):164-175. doi:10.1016/j.chest.2022.06.030
  31. Joyce BT, Chen X, Yaffe K, Henkle BE, Gao T, Zheng Y, Kalhan R, Washko G, Kunisaki KM, Thyagarajan B  et al.  Pulmonary Function in Midlife as a Predictor of Later-Life Cognition: The Coronary Artery Risk Development in Adults (CARDIA) Study.  J Gerontol A Biol Sci Med Sci  2022 Dec 29;77(12):2517-2523. doi:10.1093/gerona/glac026
  32. Young KC, Meza DA, Khuder B, Rosenberg SR, Liu GY, Kruser JM, Reyfman PA, Kalhan R  Care Fragmentation Is Associated with Increased Chronic Obstructive Pulmonary Disease Exacerbations in a U.S. Urban Care Setting.  Am J Respir Crit Care Med  2022 Oct 15;206(8):1044-1047. doi:10.1164/rccm.202112-2807LE
  33. Han MK, Ye W, Wang D, White E, Arjomandi M, Barjaktarevic IZ, Brown SA, Buhr RG, Comellas AP, Cooper CB  et al.  Bronchodilators in Tobacco-Exposed Persons with Symptoms and Preserved Lung Function.  N Engl J Med  2022 Sep 29;387(13):1173-1184. doi:10.1056/NEJMoa2204752
  34. Dransfield MT, Criner GJ, Halpin DMG, Han MK, Hartley B, Kalhan R, Lange P, Lipson DA, Martinez FJ, Midwinter D  et al.  Time-Dependent Risk of Cardiovascular Events Following an Exacerbation in Patients With Chronic Obstructive Pulmonary Disease: Post Hoc Analysis From the IMPACT Trial.  J Am Heart Assoc  2022 Sep 20;11(18):e024350. pii:e024350
  35. Stolz D, Mkorombindo T, Schumann DM, Agusti A, Ash SY, Bafadhel M, Bai C, Chalmers JD, Criner GJ, Dharmage SC  et al.  Towards the elimination of chronic obstructive pulmonary disease: a Lancet Commission.  Lancet  2022 Sep 17;400(10356):921-972. doi:10.1016/S0140-6736(22)01273-9
  36. Liu GY, Khan SS, Colangelo LA, Meza D, Washko GR, Sporn PHS, Jacobs DR, Dransfield MT, Carnethon MR, Kalhan R  Comparing Racial Differences in Emphysema Prevalence Among Adults With Normal Spirometry: A Secondary Data Analysis of the CARDIA Lung Study.  Ann Intern Med  2022 Aug;175(8):1118-1125. doi:10.7326/M22-0205
  37. Bhatt SP, Balte PP, Schwartz JE, Jaeger BC, Cassano PA, Chaves PH, Couper D, Jacobs DR, Kalhan R, Kaplan R  et al.  Pooled Cohort Probability Score for Subclinical Airflow Obstruction.  Ann Am Thorac Soc  2022 Aug;19(8):1294-1304. doi:10.1513/AnnalsATS.202109-1020OC
  38. Eckhardt CM, Balte PP, Barr RG, Bertoni AG, Bhatt SP, Cuttica M, Cassano PA, Chaves P, Couper D, Jacobs DR  et al.  Lung function impairment and risk of incident heart failure: the NHLBI Pooled Cohorts Study.  Eur Heart J  2022 Jun 14;43(23):2196-2208. doi:10.1093/eurheartj/ehac205
  39. Khan SS, Kalhan R  Comorbid Chronic Obstructive Pulmonary Disease and Heart Failure: Shared Risk Factors and Opportunities to Improve Outcomes.  Ann Am Thorac Soc  2022 Jun;19(6):897-899. doi:10.1513/AnnalsATS.202202-152ED
  40. Hu X, Qiao D, Kim W, Moll M, Balte PP, Lange LA, Bartz TM, Kumar R, Li X, Yu B  et al.  Polygenic transcriptome risk scores for COPD and lung function improve cross-ethnic portability of prediction in the NHLBI TOPMed program.  Am J Hum Genet  2022 May 05;109(5):857-870. doi:10.1016/j.ajhg.2022.03.007
  41. Bailey JI, Kalhan R  Intercepting Smoking-Related Respiratory Disease: Finding Novel Markers Beyond the Lung.  Chest  2022 Apr;161(4):867-868. doi:10.1016/j.chest.2021.12.637
  42. Georas SN, Wright RJ, Ivanova A, Israel E, LaVange LM, Akuthota P, Carr TF, Denlinger LC, Fajt ML, Kumar R  et al.  The Precision Interventions for Severe and/or Exacerbation-Prone (PrecISE) Asthma Network: An overview of Network organization, procedures, and interventions.  J Allergy Clin Immunol  2022 Feb;149(2):488-516.e9. doi:10.1016/j.jaci.2021.10.035
  43. Thatipelli S, Kershaw KN, Colangelo LA, Gordon-Larsen P, Jacobs DR, Dransfield MT, Meza D, Rosenberg SR, Washko GR, Parekh TM  et al.  Neighborhood Socioeconomic Deprivation in Young Adulthood and Future Respiratory Health: The CARDIA Lung Study.  Am J Med  2022 Feb;135(2):211-218.e1. doi:10.1016/j.amjmed.2021.07.048
  44. Wan ES, Balte P, Schwartz JE, Bhatt SP, Cassano PA, Couper D, Daviglus ML, Dransfield MT, Gharib SA, Jacobs DR  et al.  Association Between Preserved Ratio Impaired Spirometry and Clinical Outcomes in US Adults.  JAMA  2021 Dec 14;326(22):2287-2298. doi:10.1001/jama.2021.20939
  45. Ramasubramanian R, Kalhan R, Jacobs DR, Washko GR, Hou L, Gross MD, Guan W, Thyagarajan B  Gene expression of oxidative stress markers and lung function: A CARDIA lung study.  Mol Genet Genomic Med  2021 Dec;9(12):e1832. pii:e1832
  46. Ortega VE, Daya M, Szefler SJ, Bleecker ER, Chinchilli VM, Phipatanakul W, Mauger D, Martinez FD, Herrera-Luis E, Pino-Yanes M  et al.  Pharmacogenetic studies of long-acting beta agonist and inhaled corticosteroid responsiveness in randomised controlled trials of individuals of African descent with asthma.  Lancet Child Adolesc Health  2021 Dec;5(12):862-872. doi:10.1016/S2352-4642(21)00268-6
  47. Meza DA, Kalhan R  Defining Resilience: A Critical Step to Promote Respiratory Health.  Ann Am Thorac Soc  2021 Nov;18(11):1780-1781. doi:10.1513/AnnalsATS.202106-758ED
  48. Patel GB, Kudlaty EA, Guo A, Yeh C, Kim MS, Price CPE, Conley D, Grammer LC, Kalhan R, Kern RC  et al.  Impact of type 2 targeting biologics on acute exacerbations of chronic rhinosinusitis.  Allergy Asthma Proc  2021 Sep 01;42(5):417-424. doi:10.2500/aap.2021.42.210058
  49. Liu GY, Kalhan R  Impaired Respiratory Health and Life Course Transitions From Health to Chronic Lung Disease.  Chest  2021 Sep;160(3):879-889. doi:10.1016/j.chest.2021.04.009
  50. Meza D, Khuder B, Bailey JI, Rosenberg SR, Kalhan R, Reyfman PA  Mortality from COVID-19 in Patients with COPD: A US Study in the N3C Data Enclave.  Int J Chron Obstruct Pulmon Dis  2021;16:2323-2326. doi:10.2147/COPD.S318000

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